Sermorelin — Vendor Pricing & Purity Guide
Research Overview
Sermorelin is a synthetic analog of growth hormone-releasing hormone (GHRH), consisting of the first 29 amino acids of the naturally occurring 44-amino-acid GHRH molecule. It was FDA-approved in 1997 under the brand name Geref for diagnostic evaluation of pituitary function and was previously prescribed off-label for growth hormone deficiency in adults and children. Though the branded product was discontinued in 2008 due to manufacturing issues, Sermorelin remains widely available through compounding pharmacies and research peptide vendors.
Unlike exogenous growth hormone (which directly supplies GH), Sermorelin stimulates the pituitary gland to produce and release its own GH. This preserves the natural feedback loop — the hypothalamus and pituitary continue to regulate GH levels through somatostatin, preventing the supraphysiological GH spikes associated with direct GH injection. This mechanism is considered safer for long-term research applications.
Sermorelin is often positioned as the "entry-level" GHRH analog in research. While newer analogs like CJC-1295 offer longer half-lives and more potent GH stimulation, Sermorelin has the most extensive human safety data of any GH secretagogue due to its history as an FDA-approved pharmaceutical.
Key Research Findings
- •FDA-approved history (Geref) provides extensive human safety and efficacy data spanning over a decade
- •Stimulated GH release comparable to natural GHRH in diagnostic studies, confirming pituitary function preservation
- •Improved body composition (increased lean mass, decreased fat mass) in GH-deficient adults over 6-12 month treatment periods
- •Enhanced sleep quality with increased slow-wave (deep) sleep in clinical observations
- •Maintained physiological GH pulsatility unlike exogenous GH administration
- •Well-tolerated long-term with primary side effects limited to injection site reactions and transient flushing
Research Dosage Protocols
Sermorelin has well-established dosing from its history as an FDA-approved drug. Clinical protocols typically used 200-1000 mcg administered subcutaneously once daily, usually before bedtime to coincide with natural nocturnal GH release.
The peptide is supplied as lyophilized powder and reconstituted with bacteriostatic water. Due to its short half-life (~10-20 minutes), timing of administration is important in research protocols. Evening dosing before sleep is standard, as it augments the natural nighttime GH pulse.
Sermorelin is often studied in combination with GHRPs such as Ipamorelin or GHRP-2 for enhanced GH release through dual-pathway stimulation.
For research reference only. Not medical advice. Not for human consumption.
Price Comparison (22 products from 13 vendors)
| Vendor | Price | Stock |
|---|---|---|
| Paradigm Peptides | $50.00 $5.00/mg 10mg lyophilized | In Stock |
| Peptide Crafters | $55.00 $5.50/mg 10mg lyophilized | In Stock |
| Peptide Crafters | $30.00 $6.00/mg 5mg lyophilized | In Stock |
| Triumphant Labs | $64.00 $6.40/mg 10mg | In Stock |
| Polaris Peptides | $75.00 $7.50/mg 10mg lyophilized | Out |
| Peptide Sciences | $125.00 $8.33/mg 15mg lyophilized | In Stock |
| Biotech Peptides | $43.00 $8.60/mg 5mg vial | In Stock |
| Core Peptides | $88.00 $8.80/mg 10mg vial | In Stock |
| Core Peptides | $88.00 $8.80/mg 10mg vial | In Stock |
| Core Peptides | $85.00 $9.44/mg 9mg vial | In Stock |
| Core Peptides | $48.00 $9.60/mg 5mg vial | In Stock |
| Biotech Peptides | $88.00 $9.78/mg 9mg vial | In Stock |
| Pure Rawz | $39.60 $9.90/mg 4mg vial | In Stock |
| Peptide Sciences | $95.00 $10.56/mg 9mg lyophilized | In Stock |
| Peptide Sciences | $55.00 $11.00/mg 5mg lyophilized | In Stock |
| Peptide Partners | $114.00 $11.40/mg 10mg | In Stock |
| Swiss Chems | $25.95 $12.97/mg 2mg vial | In Stock |
| Peptide Sciences | $35.00 $17.50/mg 2mg lyophilized | In Stock |
| Triumphant Labs | $544.00 $54.40/mg 10mg | In Stock |
| Soma Chems | $49.99 vial | In Stock |
| Skye Peptides | $49.00 lyophilized | In Stock |
| Simple Peptide | $49.00 lyophilized | In Stock |
Frequently Asked Questions
What is Sermorelin?
Sermorelin is a synthetic version of the first 29 amino acids of GHRH (growth hormone-releasing hormone). It was FDA-approved as Geref and stimulates the pituitary to produce its own growth hormone naturally.
How does Sermorelin compare to CJC-1295?
Both are GHRH analogs, but CJC-1295 has modifications that extend its half-life significantly (especially the DAC version). Sermorelin has a short half-life (~20 min) requiring daily dosing, while CJC-1295 DAC can be dosed weekly. Sermorelin has more human safety data due to its FDA history.
Why was Sermorelin discontinued?
The branded product Geref was discontinued in 2008 due to manufacturing supply issues, not safety concerns. The peptide itself remains available through compounding pharmacies and research suppliers.
Where can I buy Sermorelin for research?
Sermorelin is available from most research peptide vendors. Compare pricing in the table above.