Ipamorelin — Vendor Pricing & Purity Guide
Research Overview
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue that stimulates growth hormone (GH) release from the anterior pituitary gland. Developed in the 1990s by Novo Nordisk, it acts as a selective agonist of the ghrelin/growth hormone secretagogue receptor (GHS-R). What distinguishes Ipamorelin from older GH secretagogues like GHRP-6 and GHRP-2 is its high selectivity — it stimulates GH release without significantly affecting cortisol, prolactin, or ACTH levels.
Ipamorelin works by mimicking ghrelin's action on the GHS receptor in the pituitary, triggering a pulse of GH release. Because it operates through the ghrelin receptor pathway (distinct from the GHRH receptor), it can be combined with CJC-1295 or Sermorelin for synergistic effect. The dual-pathway stimulation — GHRH analog plus GHRP — produces GH pulses 3-5 times greater than either peptide alone.
Among the growth hormone secretagogues, Ipamorelin is considered the "cleanest" option due to its favorable side effect profile. It does not significantly increase appetite (unlike GHRP-6), does not elevate cortisol (unlike GHRP-2 at higher doses), and produces consistent, dose-dependent GH release. This selectivity has made it one of the most popular research peptides in the GH category.
Key Research Findings
- •Dose-dependent GH release with no significant effect on cortisol, prolactin, FSH, LH, or TSH (Raun et al., 1998)
- •Synergistic GH release when combined with GHRH analogs, producing 3-5x greater GH output than monotherapy
- •Demonstrated anabolic effects on bone density in ovariectomized rat models (osteoporosis research)
- •Improved body composition parameters (lean mass increase, fat mass decrease) in growth hormone-deficient animal models
- •More selective GH release profile compared to GHRP-6 and GHRP-2, with fewer off-target hormonal effects
- •Well-tolerated in Phase I/II human studies with transient mild side effects (flushing, headache)
Research Dosage Protocols
Ipamorelin has been studied in both animal models and early-phase human clinical trials. In human studies, doses of 1 mcg/kg body weight produced significant GH elevation.
The peptide is supplied as a lyophilized powder and reconstituted with bacteriostatic water. In research protocols, it is typically administered via subcutaneous injection. Due to its short half-life (~2 hours), it is often dosed multiple times daily in research settings.
Ipamorelin is most commonly studied in combination with CJC-1295 without DAC (Mod GRF 1-29) at matched doses. The combination is typically administered on an empty stomach, as food intake (particularly fats and carbohydrates) can blunt GH release through somatostatin feedback.
For research reference only. Not medical advice. Not for human consumption.
Published Research (2 studies)
- [1]
- [2]Ipamorelin — a new GH secretagogue with selectivity for the GHS receptor— Johansen et al., 1999PMID: 10421364
Links go to PubMed (NIH National Library of Medicine). PeptideVerdict is not affiliated with these studies.
Price Comparison (39 products from 17 vendors)
| Vendor | Price | Stock |
|---|---|---|
| Paradigm Peptides | $17.99 $3.60/mg 5mg lyophilized | In Stock |
| Polaris Peptides | $50.00 $5.00/mg 10mg lyophilized | In Stock |
| Peptide Crafters | $50.00 $5.00/mg 10mg lyophilized | In Stock |
| Pure Rawz | $108.44 $5.42/mg 20mg vial | In Stock |
| Particle Peptides | $29.99 $6.00/mg 5mg lyophilized | In Stock |
| Triumphant Labs | $62.00 $6.20/mg 10mg | In Stock |
| Simple Peptide | $65.00 $6.50/mg 10mg lyophilized | In Stock |
| Skye Peptides | $69.00 $6.90/mg 10mg lyophilized | In Stock |
| Astro Peptides | $35.00 $7.00/mg 5mg capsule | Out |
| BioLongevity Labs | $79.97 $8.00/mg 10mg vial | In Stock |
| Peptide Sciences | $80.00 $8.00/mg 10mg lyophilized | In Stock |
| Core Peptides | $80.00 $8.00/mg 10mg vial | In Stock |
| Biotech Peptides | $81.00 $8.10/mg 10mg vial | In Stock |
| Peptide Partners | $82.00 $8.20/mg 10mg | In Stock |
| Paradigm Peptides | $85.00 $8.50/mg 10mg blend | In Stock |
| Core Peptides | $43.00 $8.60/mg 5mg vial | In Stock |
| Swiss Chems | $17.95 $8.97/mg 2mg vial | In Stock |
| Peptide Sciences | $46.00 $9.20/mg 5mg lyophilized | In Stock |
| Biotech Peptides | $46.00 $9.20/mg 5mg vial | In Stock |
| Peptide Sciences | $95.00 $9.50/mg 10mg lyophilized | In Stock |
| Peptide Sciences | $95.00 $9.50/mg 10mg lyophilized | In Stock |
| Peptide Crafters | $55.00 $11.00/mg 5mg blend | In Stock |
| Core Peptides | $90.00 $11.25/mg 8mg vial | In Stock |
| Biotech Peptides | $90.00 $11.25/mg 8mg vial | In Stock |
| Skye Peptides | $59.00 $11.80/mg 5mg lyophilized | In Stock |
| Polaris Peptides | $60.00 $12.00/mg 5mg lyophilized | In Stock |
| Peptide Sciences | $110.00 $13.75/mg 8mg lyophilized | In Stock |
| BioLongevity Labs | $115.00 $14.38/mg 8mg vial | In Stock |
| Peptide Sciences | $30.00 $15.00/mg 2mg lyophilized | In Stock |
| Astro Peptides | $224.00 $44.80/mg 5mg capsule | Out |
| Triumphant Labs | $527.00 $52.70/mg 10mg | In Stock |
| Astro Peptides | $392.00 $78.40/mg 5mg capsule | Out |
| Peptide Sciences | $697.00 $139.40/mg 5mg lyophilized | In Stock |
| Peptide Sciences | $697.00 $139.40/mg 5mg lyophilized | In Stock |
| Soma Chems | $29.99 vial | In Stock |
| Soma Chems | $69.99 vial | In Stock |
| Apollo Peptide Sciences | $50.00 vial | In Stock |
| Simple Peptide | $179.99 lyophilized | In Stock |
| Simple Peptide | $65.00 lyophilized | In Stock |
Frequently Asked Questions
What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide that stimulates growth hormone release by activating the ghrelin receptor in the pituitary gland. It is considered the most selective GH secretagogue, meaning it raises GH without significantly affecting cortisol, prolactin, or appetite.
Why is Ipamorelin combined with CJC-1295?
They work through different pathways — Ipamorelin through the ghrelin receptor and CJC-1295 through the GHRH receptor. Combined, they produce synergistic GH pulses 3-5x greater than either alone, mimicking the body's natural dual-signal GH release system.
How does Ipamorelin compare to GHRP-6?
Ipamorelin is more selective. GHRP-6 significantly increases appetite (via ghrelin-like hunger signaling) and can elevate cortisol at higher doses. Ipamorelin produces comparable GH release without these off-target effects.
Where can I buy Ipamorelin for research?
Ipamorelin is available from most research peptide vendors, often sold individually or as a pre-mixed combination with CJC-1295. Compare prices in the table above.