NAD+ — Vendor Pricing & Purity Guide
Research Overview
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell, essential for hundreds of metabolic processes including energy production, DNA repair, gene expression regulation, and cellular signaling. NAD+ levels decline approximately 50% between ages 20 and 50, correlating with mitochondrial dysfunction and age-related disease.
NAD+ can be supplemented directly (via IV or subcutaneous injection) or through precursors such as NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside). Direct NAD+ administration has gained popularity in research settings, though its large molecular size limits oral bioavailability. Sirtuin enzymes (SIRT1-7), which are linked to longevity pathways activated by caloric restriction, all require NAD+ as a cofactor.
Key Research Findings
- •NAD+ levels decline 50%+ between ages 20-50, correlating with mitochondrial dysfunction
- •Restoring NAD+ reversed age-related muscle deterioration in aged mice (Gomes et al., Science 2013)
- •Sirtuin enzymes require NAD+ as cofactor, linking it directly to caloric restriction longevity pathways
- •NMN (NAD+ precursor) improved insulin sensitivity in clinical trials in postmenopausal women
- •PARP DNA repair enzymes consume NAD+, meaning age-related depletion impairs DNA damage response
Research Dosage Protocols
NAD+ is available as lyophilized powder for reconstitution, typically administered via subcutaneous injection or IV infusion. IV protocols use 250-750 mg over 2-4 hours. Subcutaneous protocols use 50-200 mg daily. NAD+ injections can cause discomfort at the injection site and transient flushing.
For research reference only. Not medical advice. Not for human consumption.
Price Comparison (30 products from 16 vendors)
| Vendor | Price | Stock |
|---|---|---|
| Peptide Crafters | $105.00 $0.09/mg 1200mg lyophilized | In Stock |
| Peptide Crafters | $95.00 $0.10/mg 1000mg lyophilized | In Stock |
| Paradigm Peptides | $50.00 $0.10/mg 500mg lyophilized | In Stock |
| Simple Peptide | $65.00 $0.13/mg 500mg lyophilized | In Stock |
| Apollo Peptide Sciences | $69.99 $0.14/mg 500mg vial | In Stock |
| Peptide Crafters | $75.00 $0.15/mg 500mg lyophilized | Out |
| Triumphant Labs | $78.00 $0.16/mg 500mg | In Stock |
| Polaris Peptides | $90.00 $0.18/mg 500mg lyophilized | Out |
| Astro Peptides | $90.00 $0.18/mg 500mg lyophilized | In Stock |
| Peptide Partners | $220.00 $0.29/mg 750mg | In Stock |
| Peptide Partners | $220.00 $0.29/mg 750mg | In Stock |
| Biotech Peptides | $46.00 $0.46/mg 100mg vial | In Stock |
| Core Peptides | $47.00 $0.47/mg 100mg vial | In Stock |
| Swiss Chems | $47.95 $0.48/mg 100mg vial | In Stock |
| BioLongevity Labs | $249.97 $0.50/mg 500mg vial | In Stock |
| Peptide Sciences | $65.00 $0.65/mg 100mg lyophilized | In Stock |
| Triumphant Labs | $663.00 $1.33/mg 500mg | In Stock |
| BioLongevity Labs | $299.99 $2.50/mg 120mg vial | In Stock |
| Biotech Peptides | $79.00 $7.90/mg 10mg vial | In Stock |
| Peptide Sciences | $85.00 $8.50/mg 10mg lyophilized | In Stock |
| Core Peptides | $90.00 $9.00/mg 10mg vial | In Stock |
| Pure Rawz | $55.64 $11.13/mg 5mg vial | In Stock |
| Swiss Chems | $24.95 $12.47/mg 2mg vial | In Stock |
| Soma Chems | $49.99 spray | In Stock |
| Soma Chems | $74.99 vial | In Stock |
| Soma Chems | $49.99 vial | In Stock |
| Swiss Chems | $39.99 vial | In Stock |
| Skye Peptides | $84.00 lyophilized | In Stock |
| Simple Peptide | $59.99 lyophilized | In Stock |
| Simple Peptide | $70.00 lyophilized | In Stock |
Frequently Asked Questions
What is NAD+?
NAD+ is a coenzyme essential for cellular energy production, DNA repair, and sirtuin activation. It declines significantly with age and restoring levels is a major focus of longevity research.
Is NAD+ a peptide?
No, NAD+ is a dinucleotide coenzyme. It is sold through peptide vendors due to its prominence in anti-aging research.
What is the difference between NAD+, NMN, and NR?
NAD+ is the active coenzyme. NMN and NR are precursors the body converts into NAD+. NMN and NR are orally bioavailable; direct NAD+ typically requires injection.