5-Amino-1MQ — Vendor Pricing & Purity Guide
Research Overview
5-Amino-1MQ (5-Amino-1-Methylquinolinium) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular energy metabolism and fat storage. NNMT has emerged as a key regulator of adiposity — it is overexpressed in white adipose tissue of obese individuals and appears to promote fat cell expansion while reducing energy expenditure.
By inhibiting NNMT, 5-Amino-1MQ increases intracellular NAD+ and SAM (S-adenosylmethionine) levels, which activates SIRT1 (a longevity-associated enzyme) and shifts cellular metabolism from fat storage toward energy expenditure. This mechanism is particularly compelling because it addresses obesity at the metabolic enzyme level rather than through appetite suppression or hormonal manipulation.
5-Amino-1MQ is not technically a peptide — it is a small molecule quinolinium salt. However, it is widely sold through peptide vendors due to its metabolic research applications. It represents a newer class of anti-obesity research compound that targets epigenetic and metabolic enzyme pathways rather than the receptor-based approaches of GLP-1 agonists.
Key Research Findings
- •NNMT inhibition reduced body weight by 30% in diet-induced obese mice without changes in food intake (Neelakantan et al., 2018)
- •Increased intracellular NAD+ and SAM levels, activating SIRT1 and shifting metabolism toward energy expenditure
- •Reduced white adipose tissue mass and adipocyte size in obese mouse models
- •NNMT is overexpressed 2-3x in white adipose tissue of obese vs lean humans, validating the target
- •Reversed diet-induced metabolic dysfunction including improved glucose tolerance and lipid profiles in rodent models
- •Did not affect food intake — anti-obesity effects were entirely mediated through metabolic enzyme modulation
Research Dosage Protocols
5-Amino-1MQ is a small molecule typically supplied as a powder or in capsule form. It is orally bioavailable, meaning it does not require injection.
In published rodent studies, the compound was administered at doses of 5-20 mg/kg body weight, typically via intraperitoneal injection. Oral bioavailability data is limited in published literature.
5-Amino-1MQ is frequently sold alongside other metabolic research compounds. It represents a novel mechanism distinct from GLP-1 agonists (appetite suppression) and GH fragments (direct lipolysis) — instead targeting the NNMT enzyme at the metabolic regulation level.
For research reference only. Not medical advice. Not for human consumption.
Price Comparison (15 products from 12 vendors)
| Vendor | Price | Stock |
|---|---|---|
| Limitless Biotech | $5.00 $0.10/mg 50mg capsule | Out |
| Peptide Crafters | $85.00 $1.42/mg 60mg lyophilized | In Stock |
| Pure Rawz | $346.69 $1.69/mg 205mg capsule | In Stock |
| Chemyo | $109.99 $3.67/mg 30mg vial | In Stock |
| Swiss Chems | $189.00 $3.78/mg 50mg capsule | In Stock |
| NextChems | $189.00 $3.78/mg 50mg capsule | In Stock |
| Skye Peptides | $139.00 $3.97/mg 35mg capsule | In Stock |
| Peptide Sciences | $255.00 $5.10/mg 50mg capsule | In Stock |
| Triumphant Labs | $32.00 $6.40/mg 5mg | In Stock |
| BioLongevity Labs | $74.97 $7.50/mg 10mg vial | In Stock |
| Triumphant Labs | $270.00 $54.00/mg 5mg | In Stock |
| Limitless Biotech | $5.00 lyophilized | Out |
| Soma Chems | $79.99 vial | In Stock |
| Simple Peptide | $209.00 capsule | In Stock |
| Simple Peptide | $45.00 lyophilized | In Stock |
Frequently Asked Questions
What is 5-Amino-1MQ?
5-Amino-1MQ is a small molecule inhibitor of NNMT, a metabolic enzyme overexpressed in fat tissue. By blocking NNMT, it increases NAD+ and shifts metabolism from fat storage to energy expenditure. It reduced body weight 30% in obese mice without affecting food intake.
Is 5-Amino-1MQ a peptide?
No, it is a quinolinium salt small molecule. It is sold through peptide vendors due to its metabolic research applications and overlap with the body composition research market.
How does 5-Amino-1MQ compare to Semaglutide?
Completely different mechanisms. Semaglutide suppresses appetite through GLP-1 receptors. 5-Amino-1MQ inhibits NNMT to shift metabolic programming at the enzyme level without affecting appetite. Semaglutide has extensive human clinical data; 5-Amino-1MQ is preclinical only.
Where can I buy 5-Amino-1MQ for research?
5-Amino-1MQ is available from research peptide vendors. Compare pricing in the table above.