P21 — Benefits, Dosage & Where to Buy
Research Overview
P21 is a small tetrapeptide derived from the active region of ciliary neurotrophic factor (CNTF) that has been modified for enhanced blood-brain barrier penetration. It acts as a BDNF-mimetic compound, promoting neurogenesis in the dentate gyrus of the hippocampus while simultaneously inhibiting the activity of leukocyte common antigen-related phosphatase (LAR), which reduces tau hyperphosphorylation. In preclinical Alzheimer disease models, P21 rescued cognitive deficits, increased dendritic and synaptic density, and reduced neurofibrillary tangle pathology. The compound has attracted interest for its dual mechanism of promoting neuronal growth while countering tau-driven neurodegeneration.
Key Research Findings
- •BDNF-mimetic peptide with blood-brain barrier penetration
- •Promotes hippocampal neurogenesis in aged and AD model animals
- •Inhibits tau hyperphosphorylation via LAR phosphatase
- •Improved spatial memory and learning in preclinical Alzheimer models
- •Derived from CNTF with enhanced bioavailability
- •Dual mechanism: neurogenesis promotion + tau pathology reduction
Published Research (2 studies)
- [1]
- [2]
Links go to PubMed (NIH National Library of Medicine). PeptideVerdict is not affiliated with these studies.
Price Comparison (4 products from 4 vendors)
| Vendor | Price | Stock |
|---|---|---|
| Skye Peptides | $79.00 $7.90/mg 10mg lyophilized | In Stock |
| Soma Chems | $84.99 $8.50/mg 10mg vial | In Stock |
| Core Peptides | $116.00 $23.20/mg 5mg vial | In Stock |
| Peptide Sciences | $120.00 $24.00/mg 5mg lyophilized | In Stock |